Propofol infusion syndrome
a case report
Abstract
Propofol is a widely used anesthetic in the Intensive Care Unit. At times it may cause rather an unusual adverse reaction known as propofol infusion syndrome (PRIS), characterized by hemodynamic instability, rhabdomyolysis, lactic acidosis, and multiple-organ dysfunction. The study presents a case of PRIS with fatal outcome, including a discussion of its physiopatho logy, clinical aspects and considerations to be borne in mind when using propofol.
References
(1) Fudickar A, Bein B, Tonner PH. Propofol infusion syndrome in anaesthesia and intensive care medicine. Curr Opin Anaesthesiol 2006; 19(4):404-10.
(2) Krajeova A, Waldauf P, Andìl M, Duska F. Propofol infusion syndrome: a structured review of experimental studies and 153 published case reports. Crit Care 2015; 19:398.
(3) Merz TM, Regli B, Rothen HU, Felleiter P. Propofol infusion syndrome: a fatal case at a low infusion rate. Anesth Analg 2006; 103(4):1050.
(4) Cremer OL, Moons KG, Bouman EA, Kruijswijk JE, de Smet AM, Kalkman CJ. Long-term propofol infusion and cardiac failure in adult head-injured patients. Lancet 2001; 357(9250):117-8.
(5) Roberts RJ, Barletta JF, Fong JJ, Schumaker G, Kuper PJ, Papadopoulos S, et al. Incidence of propofol-related infusion syndrome in critically ill adults: a prospective, multicenter study. Crit Care 2009; 13(5):R169.
(6) Fong JJ, Sylvia L, Ruthazer R, Schumaker G, Kcomt M, Devlin JW. Predictors of mortality in patients with suspected propofol infusion syndrome. Crit Care Med 2008; 36(8):2281-7.
(7) Vasile B, Rasulo F, Candiani A, Latronico N. The pathophysiology of propofol infusion syndrome: a simple name for a complex syndrome. Intensive Care Med 2003; 29(9):1417- 25.
(8) Fudickar A, Bein B. Propofol infusion syndrome: update of clinical manifestation and pathophysiology. Minerva Anestesiol 2009; 75(5):339-44.
(9) Mirrakhimov AE, Voore P, Halytskyy O, Khan M, Ali AM. Propofol infusión syndrome in adults: a clinical update. Crit Care Res Pract 2015; 2015:260385.
(10) Otterspoor LC, Kalkman CJ, Cremer OL. Update on the propofol infusion syndrome in ICU management of patients with head injury. Curr Opin Anaesthesiol 2008; 21(5):544- 51.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.