Survival data analysis by biological profile of uruguayan patients with breast cancer

  • Cecilia Castillo Universidad de la República, Facultad de Medicina, Hospital de Clínicas, Servicio de Oncología Clínica. Asistente
  • Natalia Camejo Universidad de la República, Facultad de Medicina, Hospital de Clínicas, Servicio de Oncología Clínica. Ex Residente
  • Lucía Delgado Universidad de la República, Facultad de Medicina, Hospital de Clínicas, Servicio de Oncología Clínica Profesor
  • Rodrigo Fresco Universidad de la República, Facultad de Medicina, Hospital de Clínicas, Servicio de Oncología Clínica. Profesor Adjunto
  • Guianeya Santander Universidad de la República, Facultad de Medicina, Hospital de Clínicas, Servicio de Oncología Clínica. Asistente
  • Sergio Aguiar Universidad de la República. Facultad de Medicina. Hospital de Clínicas, Servicio de Oncología Radioterápica. Ex Prof. Adjunto
  • Valeria González CASMU, Departamento de Oncología Clínica. Ex Residente
  • Silvina Heinzen Universidad de la República, Facultad de Medicina, Hospital de Clínicas, Departamento Básico de Medicina. Asistente
  • Gonzalo Spera Universidad de la República, Facultad de Medicina, Hospital de Clínicas, Servicio de Oncología Clínica. Ex Residente
  • Luis Ubillos Universidad de la República, Facultad de Medicina, Hospital de Clínicas, Servicio de Oncología Clínica. Asistente
  • Franco Xavier Universidad de la República, Facultad de Medicina, Hospital de Clínicas, Servicio de Oncología Clínica. Ex Residente
  • Hugo Deneo Universidad de la República, Facultad de Medicina, Hospital de Clínicas, Cátedra de Anatomía Patológica. Prof. Agdo
  • Marta Aghazarian ASSE, Instituto Nacional del Cáncer, Departamento de Oncología Médica. Jefe
  • Robinson Rodríguez Hospital Central de las Fuerzas Armadas, Servicio de Oncología. Jefe
  • Graciela Sabini Universidad de la República, Facultad de Medicina, Hospital de Clínicas, Servicio de Oncología Clínica. Ex Prof. Directora
Keywords: SURVIVAL ANALYSIS, PROGNOSIS, BREAST NEOPLASMS, STROGEN RECEPTORS, PROGESTERONE RECEPTORS, ErbB-2 RECEPTOR

Abstract

Introduction: breast cancer constitutes an heterogeneous disease. Two sub-types have been distinguished through the study of the tumor expression level of hormone receptors tumors, and level of HER2 expression, among other techniques. We previously reported the relation between these sub-types and the clinical and pathological characteristics of Uruguayan women.
Objective: to analyse the disease-free survival (DFS) of Uruguayan patients with breast cancer, according to their biological sub-type, defined based on the tumor expression of hormone receptors and HER2 expression which were assessed by immune-histological chemistry staining.
Method: all clinical records of patients who had undergone breast cancer surgery (Stages I-III) during a two year period were reviewed. The disease-free survival rate was calculated for all patients and according to their biological profile.
Results: forty months follow up revealed disease-free survival upon two years of 92.3% for all patients; 94% for hormone receptor positive /HER2 negative patients, 91% for triple negative patients, and 71.4% for hormone receptor positive patients.
Comparing the DFS curves, for the different sub-types, evidenced a lower DFS for HER2+ patients (p = 0.03), and similar DFS for hormone receptor positive/HER2 negative and triple negative (p = 0.86).
Conclusions: uruguayan patients with breast cancer show a two-year-DFS that matches international reports. HER2+ patients evidence a higher relapse rate, also consistent with international reports. Similar DFS upon two years, between hormone receptor positive/HER2 negative patients and triple negative patients cannot be due to differences in the clinical-pathological characteristics, thus a hypothesis is considered: there is a larger proportion of patients of the luminal B breast cancer sub-type among hormone receptor positive/HER2 negative patients.

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Published
2012-12-31
How to Cite
1.
Castillo C, Camejo N, Delgado L, Fresco R, Santander G, Aguiar S, González V, Heinzen S, Spera G, Ubillos L, Xavier F, Deneo H, Aghazarian M, Rodríguez R, Sabini G. Survival data analysis by biological profile of uruguayan patients with breast cancer. Rev. Méd. Urug. [Internet]. 2012Dec.31 [cited 2024Dec.18];28(4):241-9. Available from: https://www2.rmu.org.uy/ojsrmu311/index.php/rmu/article/view/316
Issue
Vol 28 No 4 (2012): Revista Médica del Uruguay
Section
Original Articles
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