Genomic medicine applied to acute community acquired pneumonia
Keywords:
PNEUMONIA, COMMUNITY-ACQUIRED INFECTIONS, GENOMICS
Abstract
Lower respiratory tract infections constitute a serious problem for humanity. Community-acquired pneumonia is the main respiratory disease due to frequency and severity. In spite of progress made by modern medicine, mortality and morbility rates remain unchanged. Response to an infectious attack is strictly personal as it is influenced by the host's genetic structure.
Genomic medicine aims to personalize and optimize diagnosis, prognosis and treatment by acknowledging the influence of certain genetic variations, called polymorphisms, on susceptibility and the evolution of several pathologies.
Genetic polymorphisms are able to modify the risk of suffering a certain event or episode in a specific disease and being aware of this enables personalizing the interaction between the environment and the host. The present study describes polymorphisms that are positively associated to the evolution of acute-community acquired pneumonia and the possible clinical applications by genomic medicine.
References
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(40) Westendorp RG, Langermans JA, Huizinga TW, Elouali AH, Verweij CL, Boomsma DI, et al. Genetic influence on cytokine production and fatal meningococcal disease. Lancet 1997; 349(9046):170-3.
(41) Gallagher PM, Lowe G, Fitzgerald T, Bella A, Greene CM, McElvaney NG, et al. Association of IL-10 polymorphism with severity of illness in community acquired pneumonia. Thorax 2003; 58(2):154-6.
(42) Turner DM, Williams DM, Sankaran D, Lazarus M, Sinnott PJ, Hutchinson IV. An investigation of polymorphism in the interleukin-10 gene promoter. Eur J Immunogenet 1997; 24(1):1-8.
(43) Galley HF, Lowe PR, Carmichael RL, Webster NR. Genotype and interleukin-10 responses after cardiopulmonary bypass. Br J Anaesth 2003; 91(3): 424-6.
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(49) Yende S, Angus DC, Kong L, Kellum JA, Weissfeld L, Ferrell R, et al. The influence of macrophage migration inhibitory factor gene polymorphisms on outcome from community-acquired pneumonia. FASEB J 2009; 23(8):2403-11.
(50) Christians ES, Yan LJ, Benjamin IJ. Heat shock factor 1 and heat shock proteins: critical partners in protection against acute cell injury. Crit Care Med 2002; 30(1 Suppl):S43-S50.
(51) Waterer GW, ElBahlawan L, Quasney MW, Zhang Q, Kessler LA, Wunderink RG. Heat shock protein 70-2+1267 AA homozygotes have an increased risk of septic shock in adults with community-acquired pneumonia. Crit Care Med 2003; 31(5):1367-72.
(52) Determann RM, Millo JL, Garrard CS, Schultz MJ. Bronchoalveolar levels of plasminogen activator inhibitor-1 and soluble tissue factor are sensitive and specific markers of pulmonary inflammation. Intensive Care Med 2006; 32(6):946-7.
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Published
2011-04-30
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Cardinal P, Rieppi G, Bengochea M. Genomic medicine applied to acute community acquired pneumonia. Rev. Méd. Urug. [Internet]. 2011Apr.30 [cited 2024Dec.18];27(1):42-9. Available from: https://www2.rmu.org.uy/ojsrmu311/index.php/rmu/article/view/405
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