Deep vein thrombosis as a debut of acute leukemia
Abstract
The relationship between thrombosis and cáncer is widely knkown. However, this relationship is often underestimated in hematologic neoplasms, what needs to be borne in mind my clinicians. Deep vein thrombosis (DVT) may constitute the initial manifestation of acute leukemia or precede its diagnosis. The meticulous search for splenomegaly and lymphadenopathies in the clinical examination, as well as the careful analysis of complete blood count are crucial for diagnostic purposes, and has direct prognostic and therapeutic implications. The study presents the clinical case of a patient with deep vein thrombosis in the left lower limb as a debut of acute leukemia.
References
(1) Falanga A, Rickles FR. Pathophysiology of the thrombophilic state in the cancer patient. Semin Thromb Hemost 1999; 25(2):173-82.
(2) Oehadian A, Iqbal M, Sumantri R. Deep Vein Thrombosis in Acute Myelogenous Leukemia. Acta Med Indones 2009; 41(4):200-4.
(3) Colombo R, Gallipoli P, Castelli R. Thrombosis and Hemostatic Abnormalities in Hematological Malignancies. Clin Lymphoma Myeloma Leuk 2014; 14(6):441-50.
(4) Guzmán-Uribe P, Vargas-Ruíz ÁG. Thrombosis in Leukemia: Incidence, Causes, and Practical Management. Curr Oncol Rep 2015; 17(5):444.
(5) Wu YY, Tang L, Wang MH. Leukemia and Risk of Venous Thromboembolism: A Meta-analysis and Systematic Review of 144 Studies Comprising 162,126 Patients. Sci Rep. 2017; 7(1):1167.
(6) Ku GH, White RH, Chew HK, et al. Venous thromboembolism in patients with acute leukemia: incidence, risk factors, and effect on survival. Blood 2009; 113:3911-3917.
(7) De Stefano V, Sora F, Rossi E, et al. The risk of thrombosis in patients with acute leukemia: occurrence of thrombosis at diagnosis and during treatment. J Thromb Haemost 2005; 3:1985-92.
(8) Falanga A, Marchetti M, Russo L. Venous thromboembolism in the hematologic malignancies. Curr Opin Oncol 2012; 24(6):702-10.
(9) Sans-Sabrafen J, Besses Raebel C, Vives Corrons JL. Hematología Clínica. 5ª ed. Madrid: Elsevier, 2006:409-15.
(10) Argente HA, Alvarez ME. Semiología médica: fisiopatología, semiotecnia y propedéutica. Enseñanza-aprendizaje centrada en la persona. 2 ed. Buenos Aires: Médica Panamericana, 2013:1123-27.
(11) Salvatore M. Diagnóstico físico: secretos. 2ªed. España: Elsevier, 2010:467-72.
