Progressive multifocal leukoencephalopathy
A case report of a patient with HIV
Keywords:
PROGRESSIVE MULTIFOCAL LEUCOENCEPHALOPATHY, JC VIRUSES, POLYMERASE CHAIN REACTION, BIOPSY, BRAIN, HIV INFECTIONS
Abstract
A clinical case of a progressive multifocal leukoencephalopathy associated with HIV corroborated by anatomo-phatological studies is reported. Molecular biology procedures are of great importance in the analysis of the cerebrospinal fluid, especially in the polymerasa chain reaction, determining the presence of JC virus, which is directly related to the disease. Precise indication of cerebral biopsy by stereotaxya, that leads to a definitive diagnosis of progressive multifocal leukoencephalopathy, is discussed.
References
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15) Wolf M. PCR no diagnóstico das Encefalites e Meningoence-falites Virais: utilidades e limites do método. In: Mach ado L, Livramento JA, Spina-Franca A, Nóbrega JP (ed.). Neuroinfeccao 96. São Paulo: Clínica Neurológica Hospital das Clínicas. Facultad de Medicina. Universidad de Sãp Paulo/FMUSP, 1996: 23-6.
16) Bowers M. Progressive multifocal leukoencephalopathy. Bull Experiment Treat AIDS 1997: 23-6.
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2) Astrom KE, Mancall EL, Richardson EP Jr. Progressive Multifocal Encephalopathy. Brain 1958; 81: 930.
3) Cavanagh JB, Greenbaum D, Marshall AHE, et al. Cerebral Demyelination associated with disorders of reticuloendothelial system. Lancet 1959; 2: 525.
4) Richardson EP Jr. Progressive Multifocal Leukoencephalopathy. N Engl J Med 1961; 265: 815.
5) Padgett BL, Walker DL, Zu Rheim GM, Eckroade RJ, Dessel BH. Cultivation of papova-like virus from human brain with progressive multifocal leucoencephalopathy. Lancet 1971; 1: 1257-60.
6) Gillespie SM, Chang Y, Lenny G, Arthur R, Buchbinder S, Steimle A, et al. Progressive Multifocal leukoencephalopathy in persons infected with human immunodeficiency Virus, San Francisco 1981-1989. Ann Neurol 1991; 30(4): 597-604.
7) Harrison MJG, Mc Arthur JC. Opportunistic Infections-Virus in AIDS and Neurology. Tokio: Churchill-Livingstone, 1995: 141-50.
8) Yogo Y, Matsushima-Ohno T, Hayashi T, Sugimoto C, Sakurai M, Kanazawa I. JC virus regulatory region rearrangements in the brain of long surviving patient with progressive multifocal leukoencephalopathy. J Neurol Neurosurg Psychiat 2001; 71(3): 397-400.
9) Ramsay RG, Geremia GK. CNS complications of AIDS: CT and MR findings. AJR 1998; 151: 449-54.
10) Brew BJ. Progressive Multifocal Leuko-encephalopaty. Oxford: Oxford University Press, 2001: 132-41.
11) Salaverría A, Salamano R, Buzó R, Pebet M, Gordon Firing S, Chouza C. Co-infección encefálica por papovavirus (virus JC) y Varicela-Zóster en un paciente con SIDA. Arch Med Int 1998; 20(1): 19-22.
12) Cinque P, Scarpellini P, Vago L, Linde A, Lazzarin A. Diagnosis of central nervous system complications in HIV infected patients: cerebrospinal fluid analysis by the polymerase chain reaction. AIDS 1997; 11(1): 1-17.
13) Nóbrega JP. Avaliação critica da biopsia do sistema nervoso em doenças infecciosas. In: Salamano R (coord). Temas de Neuroinfectología. Montevideo: Oficina del Libro-AEM, 1998: 243-4.
14) Zunt JR, Marra C. Cerebrospinal Fluid Testing for the Diagnosis of Central Nervous System Infection. In: Marra C (ed.). Central Nervous System Infections. Neurologic Clin 1999; 17(4): 675-90.
15) Wolf M. PCR no diagnóstico das Encefalites e Meningoence-falites Virais: utilidades e limites do método. In: Mach ado L, Livramento JA, Spina-Franca A, Nóbrega JP (ed.). Neuroinfeccao 96. São Paulo: Clínica Neurológica Hospital das Clínicas. Facultad de Medicina. Universidad de Sãp Paulo/FMUSP, 1996: 23-6.
16) Bowers M. Progressive multifocal leukoencephalopathy. Bull Experiment Treat AIDS 1997: 23-6.
17) Burger P, Scheithauer B, Stephen Vogel F. The Brain: inflammatory disorders. In: Surgical pathology of The Nervous System and its Coverings. 4a ed. Philadelphia: Churchill-Livingstone, 2000: 129-32.
18) Graham D, Lantos P. Metabolic and neurodegenerative diseases. In: Greenfield's Neuropathology, 6a ed. Arnold, 1997: 471-2 (Vol. 2).
Published
2003-05-30
How to Cite
1.
Gnocchi M, Salamano R, Mañana G, Lasalvia E, Riera R, Hernández O. Progressive multifocal leukoencephalopathy. Rev. Méd. Urug. [Internet]. 2003May30 [cited 2024Dec.18];19(1):78-2. Available from: https://www2.rmu.org.uy/ojsrmu311/index.php/rmu/article/view/959
Section
Clinical Cases
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