Distal pancreatectomy with celiac axis resection for adenocarcinoma of the pancreatic body

The modified Appleby procedure

  • Javier López Sebastián Hospital San Pablo Coquimbo, Servicio Cirugía General. (Coquimbo, Chile)
  • Juan M Gamez del Castillo Hospital General del Estado de Sonora, Servicio Cirugía General. (México)
  • Álvaro Castro Fernández Hospital Maciel, Clínica Quirúrgica “3”. (Montevideo. Uruguay)
  • Elena Muñoz Corner Hospital Clínico Universitario Valencia, Servicio de Cirugía General. (Valencia,. España)
  • Carlos León Espinoza Hospital Clínico Universitario Valencia, Servicio de Cirugía General. (Valencia,. España)
  • Luis Sabater Ortí Universitat de València, Departamento de Cirugía. (España)
Keywords: PANCREATIC NEOPLASMS, DISTAL PANCREATECTOMY

Abstract

Complete oncologic resection is the only procedure that enables survival in pancreatic cancer. Compromise of the liver artery, the celiac artery or the superior mesenteric artery constitute a surgical contraidication since it is associated to a bad prognosis and it is technically hard to achieve a complete surgical resection. Only a selected group of patients who respond well to chemotherapy and may be subject to resection benefit from celiac artery resection surgery. A clinical case of adenocarcinoma of the pancreas with infiltration of the common liver artery and the celiac artery underwent a corporeo-caudal pancreatosplenectomy with celiac artery resection after a good response to neoadjuvant therapy and hepatic arterial embolization. Based on this, a review of literature on this issue and its relevant technical aspects was conducted.
The analysis performed may suggest that in duly selected cases, corporeo-caudal pancreatosplenectomy with bloc celiac artery resection is a feasible and safe procedure with good surgical and oncologic results. Upon good response to neoadjuvant chemotherapy and an experienced surgical team, this surgery seems to improve prognosis and the quality of life of these patients.

References

(1) Mollberg N, Rahbari NN, Koch M, Hartwig W, Hoeger Y, Büchler MW, et al. Arterial resection during pancreatectomy for pancreatic cancer: a systematic review and meta-analysis. Ann Surg 2011; 254(6):882-93.
(2) Alizai PH, Mahnken AH, Klink CD, Neumann UP, Junge K. Extended distal pancreatectomy with en bloc resection of the celiac axis for locally advanced pancreatic cancer: a case report and review of the literature. Case Rep Med 2012; 2012:543167.
(3) Mizutani S, Shioya T, Maejima K, Komine O, Yoshino M, Hoshino A, et al. Two successful curative operations using stomach-preserving distal pancreatectomy with celiac axis resection for the treatment of locally advanced pancreatic body cancer. J Hepatobiliary Pancreat Surg 2009; 16(2): 229-33.
(4) Müller SA, Hartel M, Mehrabi A, Welsch T, Martin DJ, Hinz U, et al. Vascular resection in pancreatic cancer surgery: survival determinants. J Gastrointest Surg 2009; 13(4):784-92.
(5) Kondo S, Katoh H, Omi M, Hirano S, Ambo Y, Tanaka E, et al. Radical distal pancreatectomy with en bloc resection of the celiac artery, plexus, and ganglions for advanced cancer of the pancreatic body: a preliminary report on perfect pain relief. JOP 2001; 2(3):93-7.
(6) Appleby LH. The coeliac axis in the expansion of the operation for gastric carcinoma. Cancer 1953; 6(4):704-7.
(7) Bonnet S, Kohneh-Shahri D, Goere D, Deshayes S, Ayadi S, Elias D. Intervention d’Appelby: place et technique en cas d’envahissement tumoral du tronc coeliaque et de ses branches. J Chir (Paris) 2009; 146(1):6-14.
(8) Nimura Y, Hattori T, Miura K, Nakashima N, Hibi M. Resection of the advanced pancreatic body-tail carcinoma by Appelby’s operation. Shujutsu 1976; 30:885-9.
(9) Hirano S, Kondo S, Hara T, Ambo Y, Tanaka E, Shichinohe T, et al. Distal pancreatectomy with en bloc celiac axis resection for locally advanced pancreatic body cancer: long-term results. Ann Surg 2007; 246(1):46-51.
(10) Mayumi T, Nimura Y, Kamiya J, Kondo S, Nagino M, Kanai M, et al. Distal pancreatectomy with en bloc resection of the celiac artery for carcinoma of the body and tail of the pancreas. Int J Pancreatol 1997; 22(1):15-21.
(11) Lin CC, Chen CL, Cheng YF. Modified extended distal pancreatectomy for carcinoma of body and tail of pancreas. Hepatogastroenterology 2005; 52(64):1090-1.
(12) Miyakawa S, Horiguchi A, Hanai T, Mizuno K, Ishihara S, Niwamoto N, et al. Monitoring hepatic venous hemoglobin oxygen saturation during Appleby operation for pancreatic cancer. Hepatogastroenterology 2002; 49(45):817-21.
Published
2016-09-30
How to Cite
1.
López Sebastián J, Gamez del Castillo JM, Castro Fernández Álvaro, Muñoz Corner E, León Espinoza C, Sabater Ortí L. Distal pancreatectomy with celiac axis resection for adenocarcinoma of the pancreatic body. Rev. Méd. Urug. [Internet]. 2016Sep.30 [cited 2024Nov.26];32(3):190-6. Available from: http://www2.rmu.org.uy/ojsrmu311/index.php/rmu/article/view/167