A case of haemophilic pseudotumor
A propósito de un caso
Keywords:
HEMOPHILIA A, HEMATOMA, NEOPLASMS
Abstract
Haemophilic pseudotumor is a rare complication in haemophiliacs and it consists of an encapsulated hematoma that gradually grows in size. The study presents the clinical case of a 17 year old patient who had a pseudotumor of the thigh, which was completely resected through surgical treatment. The pathogenesis, paraclinical studies and current treatment of the haemophilic pseudotumor are discussed. The study emphasizes on the importance of early diagnosis which allows for a planned and timely treatment that results in a reduction of the morbi-mortlity of this unusual, though important, complication of haemophilia.
References
(1) Fernández De Valderrama JA, Spain M, Matthews JM. The haemophilic pseudotumor or haemophilic subperiosteal haematoma. J Bone Joint Surg Br 1965; 47:256-65.
(2) Ahlberg AK. On the natural history of hemophilic pseudotumor. J Bone Joint Surg Am. 1975; 57(8):1133-6.
(3) Rodriguez-Merchan EC, Goddard NJ. Muscular bleeding, soft-tissue haematomas and pseudotumours. En: Rodriguez-Merchan EC, Goddard NJ, Lee CA, eds. Musculoskeletal aspects of haemophilia. Oxford: Blackwell Science, 2000: 85–91.
(4) Heim M, Martinowitz U. Pseudotumors in patients with hemophilia. En: Lee CA, Berntorp E, Hoots K, eds.Textbook of hemophilia. 2 ed. Chichester, West Sussex : Wiley Blackwell, 2010:187-90.
(5) Starker L. Knochenusur durch ein haemophiles subperiostales haematoma. Mittl Grenzgeb Med Chir 1918; 31:381-415.
(6) Rodriguez-Merchan EC. Haemophilic cysts (pseudotumours). Haemophilia 2002; 8(3):393–401.
(7) Heim M, Martinowitz U. Pseudotumors in patients with haemophilia. En: Lee CA, Berntorp E, Hoots K, eds.Textbook of hemophilia. 2 ed. Chichester, West Sussex. Wiley Blackwell, 2010:187-190
(8) Gilbert MS. Characterizing the hemophilic pseudotumor. Ann N Y Acad Sci 1975; 240:311-5.
(9) Uriza LF, Berdugo A, Partija RT, Blanco G. Pseudotumor hemofílico: reporte de caso. Univ Méd 2006; 48(1):71-4.
(10) Gómez JC. Pseudotumor hemofílico: reporte de caso clínico. Rev Mex Ortop Pediatr 2007; 9(1):25-8.
(11) García Pérez R, Torres Salmerón G, Sánchez Bueno F, García López A, Parrilla P. Pseudotumor hemofílico intraabdominal: a propósito de un caso. Rev Esp Enferm Dig 2010; 102(4):275-80.
(12) Hatzipantelis ES, Athanassiou-Metaxa M, Koussi A, Tsatra I, Badouraki M,Tsayias I, et al. Tibial pseudotumor in a child with hemophilia. Pediatr Hematol Oncol 2007; 24(8):623-30.
(13) Conde F, Lazo E, Lourido J, Domínguez J. Pseudotumor hemofílico craneal: caso clínico. Neurocirugía 2006; 17(2):158-61.
(14) van Ommeren JW, Mooren DW, Veth RP, Novakova IR, van de Kaa CA. Pseudotumor occurring in hemophilia. Arch Orthop Trauma Surg 2000; 1207-8):476-8.
(15) Moreno LA, Montoya R, Carrillo MC. Pseudotumor hemofílico. Rev Colomb Radiol 2006; 17(4):2051-4.
(16) Alper Kilic Y, Dundar S, Onat D, Akhan O. Iliopsoas hemophilic pseudotumor with bowel fistulization. Bratisl Lek Listy 2009; 110(11):729-31.
(17) Stafford JM, James TT, Allen AM, Dixon LR. Hemophilic pseudotumor: radiologic-pathologic correlation. Radiographics 2003; 23(4):852-6.
(18) Park JS, Ryu KN. Hemophilic pseudotumor involving the musculoskeletal system: spectrum of radiologic findings. AJR Am J Roentgenol 2004; 183(1):55-61.
(19) Santos M Koenigkam, Polezi M Basso, Engel E Eduard, Pastorello M Tempest, Simão M Novelino, Elias J, et al. Uncommon presentations of intraosseous hemophilic pseudotumor in imaging diagnosis. Radiol Bras 2009; 42(3):159-63.
(20) Wong IK, Munk PL, Kelly MJ. Hemophilic pseudotumor. Eurorad Radiological Case Database. Feb 14 2010. Disponible en : http://www.eurorad.org/eurorad/case.php?id=8055. Consulta: marzo 2014
(21) Ishiguro N, Iwahori Y, Kato T, Ito T, Kojima T, Takamatsu J, et al. The surgical treatment of a haemophilic pseudotumour in an extremity: a report of three cases with pathological fractures. Haemophilia 1998; 4(2):126-31.
(22) Gilbert MS, Forster A, Tariq Sohail M. A Rational approach to the treatment of hemophilic blood cyst (pseudotumor) in patients with inhibitors. En: Tariq Sohail M, Shamsi T, eds. Orthopedic management of patients with hemophilia in developing countries. Karachi (Pakistán): Ferozsons (Pvt.), 2010:169-74.
(23) Brant EE, Jordan HH. Radiologic aspects of hemophilic pseudotumors in bone. Am J Roentgenol Radium Ther Nucl Med 1972; 115(3):525-39.
(24) Espandar R, Heidari P, Rodriguez-Merchan EC. Management of haemophilic pseudotumours with special emphasis on radiotherapy and arterial embolization. Haemophilia 2009; 15(2):448-57.
(25) Nongrum B, Srinivasan R, Pandian DG, Gupta A, Krishnan M. Role of radiotherapy in hemophilic pseudotumor of the orbit. Orbit 2008; 27(5):377-9.
(26) Kang JO, Cho YJ, Yoo MC, Hong SE. Hemophilic pseudotumor of the ulna treated with low dose radiation therapy: a case report. J Korean Med Sci 2000;15(5):601-3.
(27) Pisco JM, Garcia VL, Martins JM, Mascarenhas AM. Hemophilic pseudotumor treated with transcatheter arterial embolization: case report. Angiology 1990; 41(12):1070-4.
(28) Fernández-Palazzi F, Chakal F, Viso R. Percutaneous treatment of hemophilic cysts using “Fibrin Glue”. En: Caviglia HA, Solimeno LP, eds. Orthopedic surgery in patients with hemophilia. Milan: Springer-Verlag Italia, 2008: 225-34.
(29) Caviglia H. Percutaneous treatment of hemophilic pseudotumors. J Bone Joint Surg Br 2008; 90-B(suppl 2):241.
(30) Caviglia HA, Galatro G, Vatani N. Percutaneous treatment of hemophilic pseudotumors. En: Caviglia HA, Solimeno LP, eds. Orthopedic surgery in patients with hemophilia. Milan: Springer-Verlag Italia, 2008:249-56.
(31) Caviglia HA, Fernández Palazzi F, Galatro G, Pérez Bianco R, Gilbert MS. Percutaneous treatment of haemophilic pseudotumours. En: Rodríguez-Merchan EC, Goddard NJ, Lee CA. Musculoskeletal aspects of haemophilia. Oxford: Blackwell Science, 2000:97-104.
(32) Caviglia HA, Pérez Bianco R, Tezanos Pinto M. Algoritmos terapéuticos de las complicaciones musculoesqueleticas en hemofilia. Buenos Aires: Librería Akadia, 2006.
(33) Rodríguez-Merchan EC, Goddard NJ. Muscular bleeding, soft-tissue haematomas and pseudotumours. En: Rodríguez-Merchan EC, Goddard NJ, Lee CA. Musculoskeletal aspects of haemophilia. Oxford: Blackwell Science, 2000:85-91.
(34) Heim M, Luboshitz J, Amit Y, Martinowitz U. The Management of giant haemophilic pseudotumours. En: Rodríguez-Merchan EC, Goddard NJ, Lee CA. Musculoskeletal aspects of haemophilia. Oxford: Blackwell Science, 2000:105-11.
(35) Navarro Monsoliu R, Querol Fuentes F. Rehabilitación de los hematomas musculares en los pacientes hemofílicos. Rehabilitación 2005; 39(2):59-65.
(2) Ahlberg AK. On the natural history of hemophilic pseudotumor. J Bone Joint Surg Am. 1975; 57(8):1133-6.
(3) Rodriguez-Merchan EC, Goddard NJ. Muscular bleeding, soft-tissue haematomas and pseudotumours. En: Rodriguez-Merchan EC, Goddard NJ, Lee CA, eds. Musculoskeletal aspects of haemophilia. Oxford: Blackwell Science, 2000: 85–91.
(4) Heim M, Martinowitz U. Pseudotumors in patients with hemophilia. En: Lee CA, Berntorp E, Hoots K, eds.Textbook of hemophilia. 2 ed. Chichester, West Sussex : Wiley Blackwell, 2010:187-90.
(5) Starker L. Knochenusur durch ein haemophiles subperiostales haematoma. Mittl Grenzgeb Med Chir 1918; 31:381-415.
(6) Rodriguez-Merchan EC. Haemophilic cysts (pseudotumours). Haemophilia 2002; 8(3):393–401.
(7) Heim M, Martinowitz U. Pseudotumors in patients with haemophilia. En: Lee CA, Berntorp E, Hoots K, eds.Textbook of hemophilia. 2 ed. Chichester, West Sussex. Wiley Blackwell, 2010:187-190
(8) Gilbert MS. Characterizing the hemophilic pseudotumor. Ann N Y Acad Sci 1975; 240:311-5.
(9) Uriza LF, Berdugo A, Partija RT, Blanco G. Pseudotumor hemofílico: reporte de caso. Univ Méd 2006; 48(1):71-4.
(10) Gómez JC. Pseudotumor hemofílico: reporte de caso clínico. Rev Mex Ortop Pediatr 2007; 9(1):25-8.
(11) García Pérez R, Torres Salmerón G, Sánchez Bueno F, García López A, Parrilla P. Pseudotumor hemofílico intraabdominal: a propósito de un caso. Rev Esp Enferm Dig 2010; 102(4):275-80.
(12) Hatzipantelis ES, Athanassiou-Metaxa M, Koussi A, Tsatra I, Badouraki M,Tsayias I, et al. Tibial pseudotumor in a child with hemophilia. Pediatr Hematol Oncol 2007; 24(8):623-30.
(13) Conde F, Lazo E, Lourido J, Domínguez J. Pseudotumor hemofílico craneal: caso clínico. Neurocirugía 2006; 17(2):158-61.
(14) van Ommeren JW, Mooren DW, Veth RP, Novakova IR, van de Kaa CA. Pseudotumor occurring in hemophilia. Arch Orthop Trauma Surg 2000; 1207-8):476-8.
(15) Moreno LA, Montoya R, Carrillo MC. Pseudotumor hemofílico. Rev Colomb Radiol 2006; 17(4):2051-4.
(16) Alper Kilic Y, Dundar S, Onat D, Akhan O. Iliopsoas hemophilic pseudotumor with bowel fistulization. Bratisl Lek Listy 2009; 110(11):729-31.
(17) Stafford JM, James TT, Allen AM, Dixon LR. Hemophilic pseudotumor: radiologic-pathologic correlation. Radiographics 2003; 23(4):852-6.
(18) Park JS, Ryu KN. Hemophilic pseudotumor involving the musculoskeletal system: spectrum of radiologic findings. AJR Am J Roentgenol 2004; 183(1):55-61.
(19) Santos M Koenigkam, Polezi M Basso, Engel E Eduard, Pastorello M Tempest, Simão M Novelino, Elias J, et al. Uncommon presentations of intraosseous hemophilic pseudotumor in imaging diagnosis. Radiol Bras 2009; 42(3):159-63.
(20) Wong IK, Munk PL, Kelly MJ. Hemophilic pseudotumor. Eurorad Radiological Case Database. Feb 14 2010. Disponible en : http://www.eurorad.org/eurorad/case.php?id=8055. Consulta: marzo 2014
(21) Ishiguro N, Iwahori Y, Kato T, Ito T, Kojima T, Takamatsu J, et al. The surgical treatment of a haemophilic pseudotumour in an extremity: a report of three cases with pathological fractures. Haemophilia 1998; 4(2):126-31.
(22) Gilbert MS, Forster A, Tariq Sohail M. A Rational approach to the treatment of hemophilic blood cyst (pseudotumor) in patients with inhibitors. En: Tariq Sohail M, Shamsi T, eds. Orthopedic management of patients with hemophilia in developing countries. Karachi (Pakistán): Ferozsons (Pvt.), 2010:169-74.
(23) Brant EE, Jordan HH. Radiologic aspects of hemophilic pseudotumors in bone. Am J Roentgenol Radium Ther Nucl Med 1972; 115(3):525-39.
(24) Espandar R, Heidari P, Rodriguez-Merchan EC. Management of haemophilic pseudotumours with special emphasis on radiotherapy and arterial embolization. Haemophilia 2009; 15(2):448-57.
(25) Nongrum B, Srinivasan R, Pandian DG, Gupta A, Krishnan M. Role of radiotherapy in hemophilic pseudotumor of the orbit. Orbit 2008; 27(5):377-9.
(26) Kang JO, Cho YJ, Yoo MC, Hong SE. Hemophilic pseudotumor of the ulna treated with low dose radiation therapy: a case report. J Korean Med Sci 2000;15(5):601-3.
(27) Pisco JM, Garcia VL, Martins JM, Mascarenhas AM. Hemophilic pseudotumor treated with transcatheter arterial embolization: case report. Angiology 1990; 41(12):1070-4.
(28) Fernández-Palazzi F, Chakal F, Viso R. Percutaneous treatment of hemophilic cysts using “Fibrin Glue”. En: Caviglia HA, Solimeno LP, eds. Orthopedic surgery in patients with hemophilia. Milan: Springer-Verlag Italia, 2008: 225-34.
(29) Caviglia H. Percutaneous treatment of hemophilic pseudotumors. J Bone Joint Surg Br 2008; 90-B(suppl 2):241.
(30) Caviglia HA, Galatro G, Vatani N. Percutaneous treatment of hemophilic pseudotumors. En: Caviglia HA, Solimeno LP, eds. Orthopedic surgery in patients with hemophilia. Milan: Springer-Verlag Italia, 2008:249-56.
(31) Caviglia HA, Fernández Palazzi F, Galatro G, Pérez Bianco R, Gilbert MS. Percutaneous treatment of haemophilic pseudotumours. En: Rodríguez-Merchan EC, Goddard NJ, Lee CA. Musculoskeletal aspects of haemophilia. Oxford: Blackwell Science, 2000:97-104.
(32) Caviglia HA, Pérez Bianco R, Tezanos Pinto M. Algoritmos terapéuticos de las complicaciones musculoesqueleticas en hemofilia. Buenos Aires: Librería Akadia, 2006.
(33) Rodríguez-Merchan EC, Goddard NJ. Muscular bleeding, soft-tissue haematomas and pseudotumours. En: Rodríguez-Merchan EC, Goddard NJ, Lee CA. Musculoskeletal aspects of haemophilia. Oxford: Blackwell Science, 2000:85-91.
(34) Heim M, Luboshitz J, Amit Y, Martinowitz U. The Management of giant haemophilic pseudotumours. En: Rodríguez-Merchan EC, Goddard NJ, Lee CA. Musculoskeletal aspects of haemophilia. Oxford: Blackwell Science, 2000:105-11.
(35) Navarro Monsoliu R, Querol Fuentes F. Rehabilitación de los hematomas musculares en los pacientes hemofílicos. Rehabilitación 2005; 39(2):59-65.
Published
2014-03-31
How to Cite
1.
Berro M, Acosta M, Rodríguez Cantera A, Menyou A, Insagaray J, Rodríguez Grecco I. A case of haemophilic pseudotumor. Rev. Méd. Urug. [Internet]. 2014Mar.31 [cited 2024May22];30(1):49-5. Available from: http://www2.rmu.org.uy/ojsrmu311/index.php/rmu/article/view/259
Section
Clinical Cases
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