Articular symptoms as an initial manifestation of acute lymphoblastic leukemia
Presentation of three cases
Keywords:
PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA, ARTHRITIS
Abstract
The worldwide annual incidence of acute lymphoblastic leukemia is 1.7 per 100,000 people and it constitutes the most common form of cancer in childhood. Bone and joint pain as an initial manifestation of cancer is frequent in adolescents and children, the incidence reported accounting for 1 out of three cases. The study describes three cases of acute lymphoblastic leukemia diagnosed in the Hematology Chair of the University Hospital, the initial presentation of which was arthritis, being diagnose delayed due to the low rates of suspicion.
References
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(13) Dorronsoro Martín I, Merino Muñoz R, Sastre-Urguellés A, García-Miguel García-Rosado P, García-Consuegra Molina J. Manifestaciones reumáticas como forma de comienzo de enfermedad maligna. An Pediatr (Barc.) 2004; 61(5):393-7.
(14) Serra-Bonett N, Guzmán Y, Rodríguez E, Millán A, Rodríguez MA. Leucemia aguda en niños con diagnóstico erróneo de artritis idiopática juvenil. Reumatol Clin 2008; 4(2):70-3.
(15) Marwaha RK, Kulkarni KP, Bansal D, Trehan A. Acute lymphoblastic leucemia masquerading as juvenile rheumatoid arthritis: diagnostic pitfall and association with survival. Ann Hematol 2010; 89(3):249-54.
(2) Sociedad de Hematología del Uruguay. Registro Nacional de Hemopatías Malignas. Montevideo: SHU, 2011. Disponible en: http://www.shu.com.uy/info_util_registro_leucemias.html Consulta: 30 de nov de 2012.
(3) Cabral DA, Tucker LB. Malignancies in children who initially present with rheumatic complaints. J Pediatr 1999; 134(1):53-7.
(4) Jonsson OG, Sartain P, Ducore JM, Buchanan GR. Bone pain as an initial symptom of childhood acute lymphoblastic leukemia: association with nearly normal hematologic indexes. J Pediatr 1990; 117(2 Pt 1):233-7.
(5) Barbosa CM, Nakamura C, Terreri MT, Lee ML, Petrilli AS, Hilário MO. Manifestaçoes músculo-esqueléticas como apresentaçao inicial das leucemias agudas na infancia. J Pediatr (Rio J) 2002; 78(6):481-4.
(6) Ostrov BE, Goldsmith DP, Athreya BH. Differentiation of systemic juvenile rheumatoid arthritis from acute leukemia near the onset of disease. J Pediatr 1993; 122(4):595-8.
(7) Usalan C, Ozarslan E, Zengin N, Büyükaýk Y, Güllü YH. Acute lymphoblastic leukaemia presenting with arthritis in an adult patient. Postgrad Med J 1999; 75(885):425-7.
(8) Bradlow A, Barton C. Arthritic presentation of childhood leukaemia. Postgrad Med J 1991; 67(788):562-4.
(9) Robazzi TC, Barreto JH, Silva LR, Santiago MB, Mendonça N. Osteoarticular manifestations as initial presentation of acute leukemias in children and adolescents in Bahia, Brazil. J Pediatr Hematol Oncol 2007; 29(9):622-6.
(10) Jones OY, Spencer CH, Bowyer SL, Dent PB, Gottlieb BS, Rabinovich CE. A multicenter case-control study on predictive factors distinguishing childhood leukemia from juvenile rheumatoid arthritis. Pediatrics 2006; 117(5):e840-4.
(11) Murray MJ, Tang T, Ryder C, Mabin D, Nicholson JC. Childhood leukaemia masquerading as juvenile idiopathic arthritis. BMJ 2004; 329(7472):959-61.
(12) Vargas L, Miranda M. Bone Manifestaciones osteoarticulares en la presentación inicial de la leucemia linfoblástica aguda del niño. Rev Chil Pediatr 1995; 66(2); 98-102.
(13) Dorronsoro Martín I, Merino Muñoz R, Sastre-Urguellés A, García-Miguel García-Rosado P, García-Consuegra Molina J. Manifestaciones reumáticas como forma de comienzo de enfermedad maligna. An Pediatr (Barc.) 2004; 61(5):393-7.
(14) Serra-Bonett N, Guzmán Y, Rodríguez E, Millán A, Rodríguez MA. Leucemia aguda en niños con diagnóstico erróneo de artritis idiopática juvenil. Reumatol Clin 2008; 4(2):70-3.
(15) Marwaha RK, Kulkarni KP, Bansal D, Trehan A. Acute lymphoblastic leucemia masquerading as juvenile rheumatoid arthritis: diagnostic pitfall and association with survival. Ann Hematol 2010; 89(3):249-54.
Published
2013-06-30
How to Cite
1.
Oliver C, Guadagna R, Zunino J, Guillermo C, Díaz L. Articular symptoms as an initial manifestation of acute lymphoblastic leukemia. Rev. Méd. Urug. [Internet]. 2013Jun.30 [cited 2024Nov.24];29(2):118-22. Available from: http://www2.rmu.org.uy/ojsrmu311/index.php/rmu/article/view/289
Section
Clinical Cases
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