Alopecia in pemphigus vulgaris
Keywords:
PEMPHIGUS ALOPECIA AREATA
Abstract
Pemphigus vulgaris (PV) is the most frequent form, accounting for 70% of the cases. It is an acquired autoimmune disease in which IgG antibodies target desmosomal proteins to produce intraepithelial, mucocutaneous blistering. Erosions of the scalp are a relatively ordinary clinical presentation. However, progressive loss of hair or discreet alopecic plaques are rarely described in patients with PV. The study presents a case of PV with progressive hair loss and alopecic zones.
References
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(2) Gonçalves GA, Brito MM, Salathiel A, Ferraz T, Alves D, Roselino AM. Incidence of pemphigus vulgaris exceeds that of pemphigus foliaceus in a region where pemphigus foliaceus is endemic: analysis of a 21-year historical series. An Bras Dermatol 2011; 86(6):1109-12.
(3) Mutasim DF, Bilic M, Hawayek LH, Pipitone MA, Sluzevich JC. Immunobullous diseases. J Am Acad Dermatol 2005; 52(6):1029-43.
(4) British Association of Dermatologists, Harman KE, Albert S, Black MM. Guidelines for the management of pemphigus vulgaris. Br J Dermatol 2003; 149(5):926-37.
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(8) Veraitch O, Ohyama M, Yamagami J, Amagai M. Alopecia as a rare but distinct manifestation of pemphigus vulgaris. J Eur Acad Dermatol Venereol 2013; 27(1):86-91.
(9) Castellanos IA, Guevara GE. Pénfigo vulgar. Dermatol Rev Mex 2011; 55(2):73-5.
(10) Grando SA. Pemphigus autoimmunity: hypotheses and realities. Autoimmunity 2012; 45(1):7-35.
(11) Amagai M, Stanley JR. Desmoglein as a target in skin disease and beyond. J Invest Dermatol 2012; 132(3 Pt 2):776-84.
(12) Nagasaka T, Nishifuji K, Ota T, Whittock NV, Amagai M. Defining the pathogenic involvement of desmoglein 4 in pemphigus and staphylococcal scalded skin syndrome. J Clin Invest 2004; 114(10):1484-92.
(13) Hanakawa Y, Li H, Lin C, Stanley JR, Cotsarelis G. Desmogleins 1 and 3 in the companion layer anchor mouse anagen hair to the follicle. J Invest Dermatol 2004; 123(5):817-22.
(14) Banno T, Adachi M, Mukkamala L, Blumenberg M. Unique keratinocyte-specific effects of interferon-gamma that protect skin from viruses, identified using transcriptional profiling. Antivir Ther 2003; 8(6):541-54.
(15) Sánchez Dueñas LE. Dermatoscopía en enfermedades del pelo y la piel cabelluda. Dermatol Rev Mex 2012; 56(3):187-92.
(2) Gonçalves GA, Brito MM, Salathiel A, Ferraz T, Alves D, Roselino AM. Incidence of pemphigus vulgaris exceeds that of pemphigus foliaceus in a region where pemphigus foliaceus is endemic: analysis of a 21-year historical series. An Bras Dermatol 2011; 86(6):1109-12.
(3) Mutasim DF, Bilic M, Hawayek LH, Pipitone MA, Sluzevich JC. Immunobullous diseases. J Am Acad Dermatol 2005; 52(6):1029-43.
(4) British Association of Dermatologists, Harman KE, Albert S, Black MM. Guidelines for the management of pemphigus vulgaris. Br J Dermatol 2003; 149(5):926-37.
(5) Ata-Ali F, Ata-Ali J. Pemphigus vulgaris and mucous membrane pemphigoid: update on etiopathogenesis, oral manifestations and management. J Clin Exp Dent 2011; 3(3):e246-50.
(6) Bystryn JC, Grando SA. A novel explanation for acantholysis in pemphigus vulgaris: the basal cell shrinkage hypothesis. J Am Acad Dermatol 2006; 54(3):513-6.
(7) Chmurova N, Svecova D. Pemphigus vulgaris: a 11-year review. Bratisl Lek Listy 2009; 110(8):500-3.
(8) Veraitch O, Ohyama M, Yamagami J, Amagai M. Alopecia as a rare but distinct manifestation of pemphigus vulgaris. J Eur Acad Dermatol Venereol 2013; 27(1):86-91.
(9) Castellanos IA, Guevara GE. Pénfigo vulgar. Dermatol Rev Mex 2011; 55(2):73-5.
(10) Grando SA. Pemphigus autoimmunity: hypotheses and realities. Autoimmunity 2012; 45(1):7-35.
(11) Amagai M, Stanley JR. Desmoglein as a target in skin disease and beyond. J Invest Dermatol 2012; 132(3 Pt 2):776-84.
(12) Nagasaka T, Nishifuji K, Ota T, Whittock NV, Amagai M. Defining the pathogenic involvement of desmoglein 4 in pemphigus and staphylococcal scalded skin syndrome. J Clin Invest 2004; 114(10):1484-92.
(13) Hanakawa Y, Li H, Lin C, Stanley JR, Cotsarelis G. Desmogleins 1 and 3 in the companion layer anchor mouse anagen hair to the follicle. J Invest Dermatol 2004; 123(5):817-22.
(14) Banno T, Adachi M, Mukkamala L, Blumenberg M. Unique keratinocyte-specific effects of interferon-gamma that protect skin from viruses, identified using transcriptional profiling. Antivir Ther 2003; 8(6):541-54.
(15) Sánchez Dueñas LE. Dermatoscopía en enfermedades del pelo y la piel cabelluda. Dermatol Rev Mex 2012; 56(3):187-92.
Published
2013-06-30
How to Cite
1.
Magliano J, Toloza C, Mazzei ME, Durán A, Bruno J, Martínez Asuaga M. Alopecia in pemphigus vulgaris. Rev. Méd. Urug. [Internet]. 2013Jun.30 [cited 2024Nov.24];29(2):123-6. Available from: http://www2.rmu.org.uy/ojsrmu311/index.php/rmu/article/view/290
Section
Clinical Cases
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