A case of hepatic epithelioid hemangioendo thelioma
A propósito de un caso
Keywords:
EPITHELIOID HEMANGIOENDOTELIOMA, LIVER NEOPLASMS
Abstract
Introduction: epitheloid hemangiothelioma is a mesenchymal tumour of unknown etiology and typically disseminated for diagnosis. Until today, 400 cases have been described around the world.
Method: the case of a young woman who consulted for pain in the right hypochondrium is presented. She presented tumoral hepatomegaly and splenomegaly that were imagenologically confirmed, and costal and vertebral lytic lesion. Hepatic biopsy shows high-grade epitheloid hemangiothelioma. A bibliographic review of the conditions is conducted, in particular regarding its hepatic presentation.
Results: radiotherapy to the spine for pain was initiated and the patient presented a rapid deterioration of her general condition and died as a result of sepsis of respiratory origin.
Conclusion: epitheloid hemangiothelioma must be considered in the differential diagnosis for patients seen for hepatic tumors, and surgery is the best choice of treatment.
References
(1) Palomo González MJ, Toledo Coello MD, Pérez Requena J, García Gómez N, Añón Requena MJ. Hemangioendotelioma epitelioide de pulmón: presentación de un caso con hemoptisis masiva. Rev Esp Patol 2002; 35(3): 341-4.
(2) Ishak KG, Sesterhenn IA, Goodman ZD, Rabin L, Stromeyer FW. Epithelioid hemangioendothelioma of the liver: a clinicopathologic and follow-up study of 32 cases. Hum Pathol 1984; 15(9): 839-52.
(3) Ponferrada A, Salcedo M, Matilla A, Núñez O, Bañares R, Álvarez E, et al. Heterogeneidad clínica y evolutiva del hemangioendotelioma epitelioide hepático. Gastroenterol Hepatol 2005; 28(6): 321-5.
(4) Molina Palma MI, Cervantes Góngora JA, García de la Torre E, Conde Pérez de la Blanca I, Ramírez Tortosa CL. Hemangioendotelioma epitelioide primario intraoral: presentación de un caso y revisión de la literatura. Acta Otorrinolaringol Esp 2002; 53(3): 215-8.
(5) Torres Gómez F, Rivera Hueto F, Torres Olivera F. Hemangioendotelioma epitelioide hepático primario: un simulador de metástasis. Oncología 2005; 28(6): 288-92.
(6) Mehrabi A, Kashfi A, Fonouni H, Schemmer P, Schmied BM, Hallscheidt P, et al. Primary malignant hepatic epithelioid hemangioendothelioma: a comprehensive review of the literature with emphasis on the surgical therapy. Cancer 2006; 107(9): 2108-21.
(7) Makhlouf HR, Ishak KG, Goodman ZD. Epithelioid hemangioendothelioma of the liver: a clinicopathologic study of 137 cases. Cancer 1999; 85(3): 562-82.
(8) Nudo CG, Yoshida EM, Bain VG, Marleau D, Wong P, Marotta PJ, et al. Liver transplantation for hepatic epithelioid hemangioendothelioma: the Canadian multicentre experience. Can J Gastroenterol 2008; 22(10): 821-4.
(9) Earnest F 4th, Johnson CD. Hepatic epithelioid hemangioendothelioma. Radiology 2006; 240(1): 295-8.
(10) Zhang W, Jambulingam PS, Silva MA, Taniere P, Bramhall SR, Mayer AD, et al. Orthotopic liver transplantation for epithelioid haemangioendothelioma. Eur J Surg Oncol 2007; 33(7): 898-901.
(11) Raphael C, Hudson E, Williams L, Lester JF, Savage PM. Successful treatment of metastatic hepatic epithelioid hemangioendothelioma with thalidomide: a case report. J Med Case Reports 2010; 4: 413.
(12) d'Annibale M, Piovanello P, Carlini P, Del Nonno F, Sciarretta F, Rossi M, et al. Epithelioid hemangioendothelioma of the liver: case report and review of the literature. Transplant Proc 2002; 34(4): 1248-51.
(13) Lerut JP, Orlando G, Sempoux C, Ciccarelli O, Van Beers BE, Danse E, et al. Hepatic haemangioendothelioma in adults: excellent outcome following liver transplantation. Transpl Int 2004; 17(4): 202-7.
(14) Ben-Haim M, Roayaie S, Ye MQ, Thung SN, Emre S, Fishbein TA, et al. Hepatic epithelioid hemangioendothelioma: resection or transplantation, which and when? Liver Transpl Surg 1999; 5(6): 526-31.
(15) Mascarenhas RC, Sanghvi AN, Friedlander L, Geyer SJ, Beasley HS, Van Thiel DH. Thalidomide inhibits the growth and progression of hepatic epithelioid hemangioendothelioma. Oncology 2004; 67(5-6): 471-5.
(16) Salech F, Valderrama S, Nervi B, Rodriguez JC, Oksenberg D, Koch A, et al. Thalidomide for the treatment of metastatic hepatic epithelioid hemangioendothelioma: a case report with a long term follow-up. Ann Hepatol 2011; 10(1): 99-102.
(17) Par Park MS, Ravi V, Araujo DM. Inhibiting the VEGF-VEGFR pathway in angiosarcoma, epithelioid hemangioendothelioma, and hemangiopericytoma/solitary fibrous tumor. Curr Opin Oncol 2010; 22(4): 351-5.
(18) Emamaullee JA, Edgar R, Toso C, Thiesen A, Bain V, Bigam D, et al. Vascular endothelial growth factor expression in hepatic epithelioid hemangioendothelioma: implications for treatment and surgical management. Liver Transpl 2010; 16(2): 191-7.
(2) Ishak KG, Sesterhenn IA, Goodman ZD, Rabin L, Stromeyer FW. Epithelioid hemangioendothelioma of the liver: a clinicopathologic and follow-up study of 32 cases. Hum Pathol 1984; 15(9): 839-52.
(3) Ponferrada A, Salcedo M, Matilla A, Núñez O, Bañares R, Álvarez E, et al. Heterogeneidad clínica y evolutiva del hemangioendotelioma epitelioide hepático. Gastroenterol Hepatol 2005; 28(6): 321-5.
(4) Molina Palma MI, Cervantes Góngora JA, García de la Torre E, Conde Pérez de la Blanca I, Ramírez Tortosa CL. Hemangioendotelioma epitelioide primario intraoral: presentación de un caso y revisión de la literatura. Acta Otorrinolaringol Esp 2002; 53(3): 215-8.
(5) Torres Gómez F, Rivera Hueto F, Torres Olivera F. Hemangioendotelioma epitelioide hepático primario: un simulador de metástasis. Oncología 2005; 28(6): 288-92.
(6) Mehrabi A, Kashfi A, Fonouni H, Schemmer P, Schmied BM, Hallscheidt P, et al. Primary malignant hepatic epithelioid hemangioendothelioma: a comprehensive review of the literature with emphasis on the surgical therapy. Cancer 2006; 107(9): 2108-21.
(7) Makhlouf HR, Ishak KG, Goodman ZD. Epithelioid hemangioendothelioma of the liver: a clinicopathologic study of 137 cases. Cancer 1999; 85(3): 562-82.
(8) Nudo CG, Yoshida EM, Bain VG, Marleau D, Wong P, Marotta PJ, et al. Liver transplantation for hepatic epithelioid hemangioendothelioma: the Canadian multicentre experience. Can J Gastroenterol 2008; 22(10): 821-4.
(9) Earnest F 4th, Johnson CD. Hepatic epithelioid hemangioendothelioma. Radiology 2006; 240(1): 295-8.
(10) Zhang W, Jambulingam PS, Silva MA, Taniere P, Bramhall SR, Mayer AD, et al. Orthotopic liver transplantation for epithelioid haemangioendothelioma. Eur J Surg Oncol 2007; 33(7): 898-901.
(11) Raphael C, Hudson E, Williams L, Lester JF, Savage PM. Successful treatment of metastatic hepatic epithelioid hemangioendothelioma with thalidomide: a case report. J Med Case Reports 2010; 4: 413.
(12) d'Annibale M, Piovanello P, Carlini P, Del Nonno F, Sciarretta F, Rossi M, et al. Epithelioid hemangioendothelioma of the liver: case report and review of the literature. Transplant Proc 2002; 34(4): 1248-51.
(13) Lerut JP, Orlando G, Sempoux C, Ciccarelli O, Van Beers BE, Danse E, et al. Hepatic haemangioendothelioma in adults: excellent outcome following liver transplantation. Transpl Int 2004; 17(4): 202-7.
(14) Ben-Haim M, Roayaie S, Ye MQ, Thung SN, Emre S, Fishbein TA, et al. Hepatic epithelioid hemangioendothelioma: resection or transplantation, which and when? Liver Transpl Surg 1999; 5(6): 526-31.
(15) Mascarenhas RC, Sanghvi AN, Friedlander L, Geyer SJ, Beasley HS, Van Thiel DH. Thalidomide inhibits the growth and progression of hepatic epithelioid hemangioendothelioma. Oncology 2004; 67(5-6): 471-5.
(16) Salech F, Valderrama S, Nervi B, Rodriguez JC, Oksenberg D, Koch A, et al. Thalidomide for the treatment of metastatic hepatic epithelioid hemangioendothelioma: a case report with a long term follow-up. Ann Hepatol 2011; 10(1): 99-102.
(17) Par Park MS, Ravi V, Araujo DM. Inhibiting the VEGF-VEGFR pathway in angiosarcoma, epithelioid hemangioendothelioma, and hemangiopericytoma/solitary fibrous tumor. Curr Opin Oncol 2010; 22(4): 351-5.
(18) Emamaullee JA, Edgar R, Toso C, Thiesen A, Bain V, Bigam D, et al. Vascular endothelial growth factor expression in hepatic epithelioid hemangioendothelioma: implications for treatment and surgical management. Liver Transpl 2010; 16(2): 191-7.
Published
2011-06-30
How to Cite
1.
dos Santos G, Collazo C, Maciel G. A case of hepatic epithelioid hemangioendo thelioma. Rev. Méd. Urug. [Internet]. 2011Jun.30 [cited 2024Nov.26];27(2):94-7. Available from: http://www2.rmu.org.uy/ojsrmu311/index.php/rmu/article/view/395
Section
Clinical Cases
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