Effective dose associated to hybrid SPECT-CT imaging in adult patients

  • Lucas Rodríguez Universidad de la República, Facultad de Medicina, Escuela Universitaria de Tecnología Medica, Lic. en Imagenología
  • Matías Rodríguez Universidad de la República, Facultad de Medicina, Escuela Universitaria de Tecnología Medica, Lic. en Imagenología
  • Agustina Roberts Universidad de la República, Facultad de Medicina, Escuela Universitaria de Tecnología Medica, Lic. en Imagenología
  • Natalia Viera Universidad de la República, Facultad de Medicina, Escuela Universitaria de Tecnología Medica, Prof. Adj. Imagenología
  • Natalia Huart Universidad de la República, Facultad de Medicina, Escuela Universitaria de Tecnología Medica, Prof. Adj. Imagenología, Prof. Agda. Directora
  • Sergio Rodríguez Universidad de la República, Facultad de Medicina, Tecnicatura en Radioisótopos, Doc. Ayud.
  • Enzo Silvera Universidad de la República, Facultad de Medicina, Departamento de Medicina Nuclear e Imagenología Molecular, Doc. Asist.
  • Juan Carlos Hermida Universidad de la República, Facultad de Medicina, Departamento de Medicina Nuclear e Imagenología Molecular, Prof. Agdo.
  • Omar Alonso Universidad de la República, Facultad de Medicina, Departamento de Medicina Nuclear e Imagenología Molecular, Prof. Dr. Jefe
Keywords: SPECT-CT, EFFECTIVE DOSE, PROTOCOL, NUCLEAR MEDICINE, RADIATION PROTECTION

Abstract

Introduction: SPECT-CT Hybrid image technique combines the SPECT (single-photon emission computed tomography) image with the CT (computerized tomography) image to obtain both functional and anatomical images in the same study. The total effective ionizing radiation dose received in SPECT-CT studies may be estimated based on the effective dose from the radiopharmaceutical administered and the effective dose from the CT (computerized tomography) component.
Objectives: the study aims to estimate the total effective dose in SPECT-CT protocols applied for the adult population, and to determine the additional contribution from the CT component to the total effective dose.
Method: 258 SPECT-CT studies were evaluated to estimate the total effective dose from the administration of radiopharmaceuticals and low dose CT studies. Specific conversion factors for each radiopharmaceutical and area of the body explored with the CT were used to estimate radiation doses from both components.
Results: total effective dose (average ± SD) in the SPECT-CT studies was: 12.4 ± 1.44 mSv in the myocardial perfusion study, 1.14 ± 0.25 mSv in the breast sentinel lymph node study,  8.6 ± 0.6 mSv in the parathyroid study, 1.48 ± 1.02 mSv in the thyroid study. As to bone studies, doses found were: 4.5 ± 0.3, in neck studies, 6.07 ± 0.3 mSv in thoracic studies and 6.1 ± 0.3 mSv in abdominal and pelvic studies.  The radiation dose from the CT study ranges from 0.46 mSv for the thoracic region on the breast sentinel lymph node study to 2.3 mSv for the bone SPECT-CT study of the abdominal and pelvic region.
Conclusions: we managed to estimate the effective dose in the the most frequently used SPECT-CT protocols for the adult population and the contribution of CT studies to the total effective dose. It was found to be relatively low when compared to the dose contributed by the radiopharmaceuticals administered, with the exception of the sentinel lymph node study for which the contribution from the CT study is approximately half the total effective dose.

References

1) Mariani G, Bruselli L, Kuwert T, Kim EE, Flotats A, Israel O, et al. A review on the clinical uses of SPECT/CT. Eur J Nucl Med Mol Imaging 2010; 37(10):1959-85. doi: 10.1007/s00259-010-1390-8.
2) Perera Pintado A, Torres Aroche L, Vergara Gil A, Batista Cuéllar J, Prats Capote A. SPECT/CT: principales aplicaciones en la medicina nuclear. Nucleus (La Habana) 2017; (62):2-9.
3) Kuwert T. Skeletal SPECT/CT: a review. Clin Transl Imaging 2014; 2(6):505-17. doi: 10.1007/s40336-014-0090-y.
4) ICRP Publication 105. Radiation protection in medicine. Ann ICRP 2007; 37(6):1-63. doi: 10.1016/j.icrp.2008.08.001.
5) Baert AL, ed. Encyclopedia of Diagnostic Imaging. Heidelberg: Springer, 2008. doi: 10.1007/978-3-540-35280-8_87.
6) Mattsson S, Johansson L, Leide Svegborn S, Liniecki J, Noßke D, Riklund K, et al. Radiation dose to patients from radiopharmaceuticals: a compendium of current information related to frequently used substances. Ann ICRP 2015; 44(2 Suppl):7-321. doi: 10.1177/0146645314558019.
7) Cheetham AM, Havariyoun G, Kalogianni E, Ruiz D, Devlin L, Gulliver N, et al. Calculating the effective dose from the CT component of a SPECT/CT Study. Eur J Nucl Med Mol Imaging 2016; 43(Suppl 1):S641.
8) Ferrari M, De Marco P, Origgi D, Pedroli G. SPECT/CT radiation dosimetry. Clin Transl Imaging 2014; 2(6):557-69. doi: 10.1007/s40336-014-0093-8.
9) Deak PD, Smal Y, Kalender WA. Multisection CT protocols : sex- and age-specific conversion dose from dose-length product. Radiology 2010; 257(1):158-66. doi: 10.1148/radiol.10100047.
10) Israel O, Pellet O, Biassoni L, De Palma D, Estrada-Lobato E, Gnanasegaran G, et al. Two decades of SPECT/CT – the coming of age of a technology: an updated review of literature evidence. Eur J Nucl Med Mol Imaging 2019; 46(10):1990-2012. doi: 10.1007/s00259-019-04404-6.
11) Nuñez M. Cardiac SPECT. Alasbimn Journal 2002; 5(18). Article N° AJ18-13. Disponible en: http://web.uchile.cl/vignette/borrar3/alasbimn/CDA/sec_b/0,1206,SCID%253D568,00.html [Consulta: 24 setiembre 2021].
12) Camacho López C, Martí Vidal JF, Falgás Lacueva M, Vercher Conejero JL. Dosis efectivas asociadas a las exploraciones multimodales habituales en medicina nuclear. Rev Esp Med Nucl 2011; 30(5):276-85. doi: 10.1016/j.remn.2011.02.008.
13) Rausch I, Füchsel FG, Kuderer C, Hentschel M, Beyer T. Radiation exposure levels of routine SPECT/CT imaging protocols. Eur J Radiol 2016; 85(9):1627-36. doi: 10.1016/j.ejrad.2016.06.022.
14) Public Health England. National Diagnostic Reference Levels (NDRLs) from 19 August 2019. Disponible en: https://www.gov.uk/government/publications/diagnostic-radiology-national-diagnostic-reference-levels-ndrls/ndrl [Consulta: 15 enero 2022].
15) Puerta-Ortiz JA; Morales-Aramburo J. Efectos biológicos de las radiaciones ionizantes. Rev Colomb Cardiol 2020; 27(S1):61-71. Disponible en: https://www.elsevier.es/es-revista-revista-colombiana-cardiologia-203-articulo-efectos-biologicos-radiaciones-ionizantes-S0120563320300061 [Consulta: 16 febrero 2022].
16) Soria Jerez JA. Radiación y dosimetría. En: Costa Subias J, Soria Jerez JA. Tomografía computarizada dirigida a técnicos superiores en imagen para el diagnóstico. Barcelona: Elsevier, 2015:90-7.
17) Uruguay. Ministerio de Industria, Energía y Minería. Autoridad Reguladora Nacional en Radioprotección. Justificación de las exposiciones médicas en el diagnóstico por imágenes con radiaciones ionizantes. Montevideo: MIEM–ARNR, 2019.
18) Ubeda de la C C, Vaño E, Ruiz R, Soffia P, Fabri D. Niveles de referencia para diagnóstico: una herramienta efectiva para la protección radiológica de pacientes. Rev Chil Radiol 2019; 25(1):19-25. doi: 10.4067/S0717-93082019000100019.
19) Azpeitia Arman FJ, Puig Domingo J, Soler Fernández R. Sistema endocrino. En: Sociedad Española de Radiología Médica; Azpeitia Arman FJ, Puig Domingo J, Soler Fernández R. Manual para técnico superior en imagen para el diagnóstico y medicina nuclear. Madrid: Panamericana, 2016:87-93.
20) Andersson M, Johansson L, Minarik D, Leide-Svegborn S, Mattsson S. Effective dose to adult patients from 338 radiopharmaceuticals estimated using ICRP biokinetic data, ICRP/ICRU computational reference phantoms and ICRP 2007 tissue weighting factors. EJNMMI Phys 2014; 1(1):9. doi: 10.1186/2197-7364-1-9.
Published
2022-10-12
How to Cite
1.
Rodríguez L, Rodríguez M, Roberts A, Viera N, Huart N, Rodríguez S, Silvera E, Hermida JC, Alonso O. Effective dose associated to hybrid SPECT-CT imaging in adult patients. Rev. Méd. Urug. [Internet]. 2022Oct.12 [cited 2024Nov.17];38(3):e38310. Available from: http://www2.rmu.org.uy/ojsrmu311/index.php/rmu/article/view/898