Dislipemia y lipodistrofia en niños uruguayos vih positivos en tratamiento antirretroviral

Stella Gutiérrez; Myriam De León; Leticia Cuñetti; Gabriela Gutiérrez; Verónica Giménez; Jorge Quian

Stella Gutiérrez Universidad de la República, Facultad de Medicina, Centro Hospitalario Pereira Rossell, Pediatría, Prof. Agdo. Policlínica de Seguimiento de Niños VIH-SIDA
Myriam De León Universidad de la República, Facultad de Medicina, Centro Hospitalario Pereira Rossell, Nutrición Clínica, Prof. Adj. Licenciado en Nutrición. Policlínica de Seguimiento de Niños VIH-SIDA
Leticia Cuñetti Universidad de la República, Facultad de Medicina, Centro Hospitalario Pereira Rossell, Departamento de Farmacología y Terapéutica, Médico, Asistente. Policlínica de Seguimiento de Niños VIH-SIDA
Gabriela Gutiérrez Universidad de la República, Facultad de Medicina, Centro Hospitalario Pereira Rossell, Laboratorio Clínico, Médico, Asistente. Policlínica de Seguimiento de Niños VIH-SIDA
Verónica Giménez Universidad de la República, Facultad de Medicina, Centro Hospitalario Pereira Rossell, Licenciado en Nutrición. Policlínica de Seguimiento de Niños VIH-SIDA
Jorge Quian Universidad de la República, Facultad de Medicina, Centro Hospitalario Pereira Rossell, Pediatría, Prof. Agdo. Policlínica de Seguimiento de Niños VIH-SIDA

Keywords: ANTIRETROVIRAL AGENTS, LIPODYSTROPHY, DYSLIPIDEMIAS, HIV INFECTIONS, CHILD

Abstract

Background: Survival of HIV infected patients has improved with Hightly Active Anti-Retroviral Therapy but adverse effects have come out.
Our aim is to describe lipodistrophy and dyslipidemia in HIV infected children under treatment; and to lypodistrophy - dislipidemia/stage of disease - length of treatment.
Methods: The transversal descriptive study defines lipoatrophy as infant with normal body mass index (BMI/IMC) and tricipital skin-fold thickness < 5p or sunken cheeks or both; lipohypertrophy as normal body mass index and subscapular skin-fold > 90p or central fat disposition; combined lipodystrophy when both are present. Hypertriglyceridemia and hypercholesterolemia were defined as > 90p according to tables of reference.
Length of treatment was classified as < 5 years and stage of disease.
Results were expressed as percents, CI 95%. We used the c2 test.
Results: Sixty children aged 6.8 + 3.3 years were included in the study. Lypodystrophy was seen in 13 (21.7%, CI 95% 12.5-34.5) and dyslipidemia in 33 (55%, CI 95% 41.7-67.7). Neither dyslipidemia nor lipodystrophy were associated with stages of the disease. Combined dyslipidemia was predominant in children under at least 5 years of treatment, which was different in cases of hypertrigly-ceridemia. Lipodystrophy was not associated with length of treatment.
Conclusions: Lipodystrophy and dyslipidemia are frequent alterations. Lipid monitoring and body composition are essential to bring up healthier children.

References

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Dyslipidemia and lipodistrophy in HIV Uruguayan children under anti-retroviral therapy (HAART)

Abstract

References

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